Phospho-SNAI1 (Ser246) Antibody - Cat. #: CSB-PA299638

SKU: CSB-PA299638

Size :100ul

Clone Number:

Aliases:dJ710H13.1 antibody; Protein sna antibody; Protein snail homolog 1 antibody; Protein snail homolog antibody; SLUGH2 antibody; SNA antibody; Sna protein antibody; SNAH antibody; SNAI antibody; snai1 antibody; SNAI1_HUMAN antibody; Snail 1 homolog antibody; Snail 1 zinc finger protein antibody; SNAIL antibody; Snail family transcriptional repressor 1 antibody; Snail homolog 1 (Drosophila) antibody; SNAIL, Drosophila, homolog of, 1 antibody; SNAIL1 antibody; Zinc finger protein SNAI1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O95863

Immunogen:Peptide sequence around phosphorylation site of Serine 246(T-F-S(p)-R-M) derived from Human SNAI1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SNAI1

Research Areas:Epigenetics and Nuclear Signaling;Cancer?Cardiovascular