Phospho-NPM1 (Thr199) Antibody - Cat. #: CSB-PA582765

SKU: CSB-PA582765

Size :100ul

Clone Number:

Aliases:B23 antibody; MGC104254 antibody; NO38 antibody; NPM antibody; NPM_HUMAN antibody; NPM1 antibody; Nucleolar phosphoprotein B23 antibody; Nucleolar protein NO38 antibody; Nucleophosmin (nucleolar phosphoprotein B23 numatrin) antibody; Nucleophosmin antibody; nucleophosmin nucleoplasmin family member 1 antibody; Nucleophosmin/nucleoplasmin family member 1 antibody; Numatrin antibody; OTTHUMP00000161024 antibody; OTTHUMP00000161025 antibody; OTTHUMP00000223397 antibody; OTTHUMP00000223398 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P06748

Immunogen:Peptide sequence around phosphorylation site of Threonine 199(R-D-T(p)-P-A) derived from Human NPM.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NPM1

Research Areas:Epigenetics and Nuclear Signaling