PHF2 antibody , Cat. # FNab06384

SKU: FNab06384

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3(H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3(H3K4me3) at rDNA promoters and promotes expression of rDNA.

Immunogen:PHD finger protein 2

Synonyms:GRC5, JHDM1E, KIAA0662, PHD finger protein 2, PHF2

Observed MW:100 kDa, 150 kDa

Uniprot ID:O75151

Reactivity:Human

Tested Application:ELISA, WB, IHC, IP

Recommended dilution:WB: 1:200-1:1000; IP: 1:500-1:1000; IHC: 1:20-1:200

Gene ID:5253

Research Area:Epigenetics, Metabolism