PFKFB3 Polyclonal Antibody

SKU: E-AB-53523

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:PFKFB3

Target Synonym:Renal Carcinoma Antigen NY-REN-56;PFK/FBPase 3;IPFK2;PFK2

Research Areas:Cardiovascular;Signal Transduction;Neuroscience;Cancer;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Rat

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q16875

Accession:

Background:The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Concentration:0.5 mg/mL

Immunogen:Synthetic peptide of human PFKFB3

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:WB 1:500-1:2000

Calculated MW:60 kDa

ObservedMW:Refer to figures