PDHA1 Monoclonal Antibody

SKU: BT-MCA3345

Size:100μL

Background:The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research_area:Signal Transduction, Metabolism

Target_protein:PDHA1

applications:WB, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:2A2H7

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:PDHA1

Immunogen:Purified recombinant fragment of human PDHA1 (AA: 241-390) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):43.3kDa

UniProt accession:P08559

Synonyms:PDHA, PDHAD, PHE1A, PDHCE1A

GeneID:5160