PCSK5 Rabbit Polyclonal Antibody

SKU: BT-AP11845

Size:100μL

Background:This gene encodes a member of the subtilisin-like proprotein convertase family| which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the Catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin| pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants| some of which encode distinct isoforms| including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).

Research_area:Cell biology; Signal transduction

Target_protein:PCSK5

applications:WB

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:PCSK5

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):204600

UniProt accession:Human: Q92824; Mouse: Q04592; Rat: P41413

Synonyms:PCSK5

GeneID:Human: 5125; Mouse: 18552; Rat: 116548