PCID2 Antibody - Cat. #: CSB-PA705514LA01HU

SKU: CSB-PA705514LA01HU

Size :50ug

Clone Number:

Aliases:CSN12 like protein antibody; CSN12-like protein antibody; DKFZp686C20226 antibody; F10 antibody; FLJ11305 antibody; FLJ99362 antibody; HT004 antibody; MGC16774 antibody; PCI domain containing 2 antibody; PCI domain containing protein 2 antibody; PCI domain-containing protein 2 antibody; PCID2 antibody; PCID2_HUMAN antibody; RP11 - 98F14.6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q5JVF3

Immunogen:Recombinant Human PCI domain-containing protein 2 protein (2-250AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200

Background:Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PCID2

Research Areas:Cell biology