PAK3 Antibody, FITC conjugated - Cat. #: CSB-PA017407LC01HU

SKU: CSB-PA017407LC01HU

Size :50ug

Clone Number:

Aliases:PAK3 antibody; OPHN3 antibody; Serine/threonine-protein kinase PAK 3 antibody; EC 2.7.11.1 antibody; Beta-PAK antibody; Oligophrenin-3 antibody; p21-activated kinase 3 antibody; PAK-3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O75914

Immunogen:Recombinant Human Serine/threonine-protein kinase PAK 3 protein (70-190AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PAK3

Research Areas:Neuroscience; Signal transduction