ORC1 Polyclonal Antibody

SKU: E-AB-52668

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:ORC1

Target Synonym:HSORC1;MmORC1;orc1;ORC1;ORC1L;Origin Recognition Complex 1;Origin recognition complex subunit 1 (yeast homolog) like;Origin recognition complex subunit 1;Origin recognition complex subunit 1 homolog;Origin recognition complex subunit 1 like (S. cerevisia;Origin recognition complex subunit 1 like;Origin recognition complex subunit 1 S. cerevisiae homolog like ;Origin recognition complex;subunit 1 like (yeast);PARC1;Replication control protein 1

Research Areas:Epigenetics and Nuclear Signaling

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q13415

Accession:

Background:The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.ORC1 (Origin Recognition Complex Subunit 1) is a Protein Coding gene. Diseases associated with ORC1 include Meier-Gorlin Syndrome 1 and Microtia. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include chromatin binding. An important paralog of this gene is CDC6.

Concentration:1.14 mg/mL

Immunogen:Fusion protein of human ORC1

Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Purification method:Antigen affinity purification

Dilution:IHC 1:50-1:300

Calculated MW:

ObservedMW: