NRG1 Antibody, Biotin conjugated - Cat. #: CSB-PA09589D0Rb

SKU: CSB-PA09589D0Rb

Size :50ug

Clone Number:

Aliases:Acetylcholine receptor-inducing activity antibody; Acetylcholine receptor-inducing activity, chick, homolog of antibody; ARIA antibody; Breast cancer cell differentiation factor p45 antibody; GGF antibody; GGF2 antibody; glial growth factor 2 antibody; Glial growth factor antibody; Heregulin antibody; heregulin, alpha (45kD, ERBB2 p185-activator) antibody; heregulin, alpha antibody; HGL antibody; HRG antibody; HRG1 antibody; HRGA antibody; MST131 antibody; MSTP131 antibody; NDF antibody; Neu differentiation factor antibody; Neuregulin-1 antibody; nrg1 antibody; NRG1-IT2 antibody; NRG1_HUMAN antibody; Pro-NRG1 antibody; Sensory and motor neuron-derived factor antibody; SMDF antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q02297

Immunogen:Recombinant Human Pro-neuregulin-1, membrane-bound isoform protein (75-176AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NRG1

Research Areas:Neuroscience; Signal transduction