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Gene Bio Systems

NPRL2 Antibody - Cat. #: CSB-PA840976ESR1HU

NPRL2 Antibody - Cat. #: CSB-PA840976ESR1HU

CSB-PA840976ESR1HU

$409.00 USD
$409.00 USD
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Size :50ul

Clone Number:

Aliases:2810446G01Rik antibody; G21 protein antibody; Gene 21 protein antibody; Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody; Homologous to yeast nitrogen permease antibody; Nitrogen permease regulator 2-like protein antibody; Nitrogen permease regulator-like 2 (S. cerevisiae) antibody; NPR 2L antibody; NPR L2 antibody; NPR like 2 antibody; NPR2 antibody; NPR2 like antibody; NPR2-like protein antibody; NPR2L antibody; NPRL 2 antibody; NPRL2 antibody; NPRL2_HUMAN antibody; Tumor suppressor candidate 4 antibody; TUSC 4 antibody; TUSC 4 protein antibody; TUSC4 antibody; TUSC4 protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WTW4

Immunogen:Recombinant Human Nitrogen permease regulator 2-like protein (1-220AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200

Background:Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at \\\'Tyr-9\\\', \\\'Tyr-373\\\' and \\\'Tyr-376\\\' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NPRL2

Research Areas:Epigenetics and Nuclear Signaling; Cancer

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