NLTP rabbit pAb

SKU: ES14479

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human; Mouse;Rat

Dilution:WB 1：500-2000

Immunogen:Synthesized peptide derived from human NLTP AA range: 338-388

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):

Human_gene_id:6342

Human_swiss_prot_no:P22307

Subcellular_location:[Isoform SCP2]: Peroxisome . Cytoplasm . Mitochondrion . Endoplasmic reticulum . Mitochondrion .; [Isoform SCPx]: Peroxisome .

Other_name:

Background:This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010],