NGEF antibody , Cat. # FNab05720

SKU: FNab05720

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).

Immunogen:neuronal guanine nucleotide exchange factor

Synonyms:

Observed MW:75 kDa

Uniprot ID:Q8N5V2

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IP, IHC

Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:50-1:500

Gene ID:25791

Research Area:Developmental biology