NGEF Antibody - Cat. #: CSB-PA850809LA01HU

SKU: CSB-PA850809LA01HU

Size :50ul

Clone Number:

Aliases:ARHGEF27 antibody; Eph receptor-interacting exchange protein antibody; Eph-interacting exchange protein antibody; EPHEXIN antibody; Ephexin-1 antibody; Guanine nucleotide exchange factor, neuronal antibody; Neuronal guanine nucleotide exchange factor antibody; Ngef antibody; NGEF_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8N5V2

Immunogen:Recombinant Human Ephexin-1 protein (495-710AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200

Background:Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NGEF

Research Areas:Neuroscience; Signal transduction