NFKB1 Monoclonal Antibody

SKU: BT-MCA3715

Size:100μL

Background:This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.

Research_area:Cell Biology

Target_protein:NFKB1

applications:WB, IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:5D10D11

Host:Mouse

Isotype:Mouse IgG2a

Gene Symbol/ Name:NFKB1

Immunogen:Purified recombinant fragment of human NFKB1 expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):50kDa|105kDa

UniProt accession:P19838

Synonyms:p50, KBF1, p105, EBP-1, MGC54151, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B

GeneID:4790