NEIL1 Antibody - Cat. #: CSB-PA846619LA01HU

SKU: CSB-PA846619LA01HU

Size :50ug

Clone Number:

Aliases:DNA (apurinic or apyrimidinic site) lyase Neil1 antibody; DNA glycosylase/AP lyase Neil 1 antibody; DNA glycosylase/AP lyase Neil1 antibody; DNA-(apurinic or apyrimidinic site) lyase Neil1 antibody; Endonuclease 8 like 1 antibody; Endonuclease 8-like 1 antibody; Endonuclease VIII antibody; Endonuclease VIII like 1 antibody; Endonuclease VIII-like 1 antibody; FLJ22402 antibody; FPG1 antibody; hFPG1 antibody; NEH 1 antibody; NEH1 antibody; NEI 1 antibody; Nei endonuclease VIII like 1 (E. coli) antibody; Nei endonuclease VIII like 1 antibody; Nei homolog 1 antibody; Nei like 1 antibody; Nei like protein 1 antibody; Nei-like protein 1 antibody; NEI1 antibody; NEIL 1 antibody; Neil1 antibody; NEIL1_HUMAN antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96FI4

Immunogen:Recombinant Human Endonuclease 8-like 1 protein (2-390AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3\'- and 5\'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NEIL1

Research Areas:Epigenetics and Nuclear Signaling