Na+/K+-ATPase α2 rabbit pAb

SKU: ES6362

Size: 100μL

Source:Rabbit

Applications:WB;ELISA;IHC

Reactivity:Human;Mouse;Rat;Monkey

Dilution:WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

Immunogen:The antiserum was produced against synthesized peptide derived from human ATP1A2. AA range:971-1020

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):112kD

Human_gene_id:477

Human_swiss_prot_no:P50993

Subcellular_location:Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .

Other_name:ATP1A2; KIAA0778; Sodium/potassium-transporting ATPase subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2

Background:The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008],