MUC16 Monoclonal Antibody

SKU: BT-MCA3058

Size:100μL

Background:This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes.

Research_area:Tags & Cell Markers

Target_protein:MUC16

applications:FCM

Reactivity:

Clonality:Monoclonal

Clone ID:1E1B9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MUC16

Immunogen:Purified recombinant fragment of human MUC16 (AA: extra 1-200) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):1519kDa

UniProt accession:Q8WXI7

Synonyms:CA125

GeneID:94025