MSH6 Monoclonal Antibody

SKU: BT-MCA4844

Size:100μL

Background:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

Research_area:Others

Target_protein:MSH6

applications:WB, IHC, FCM

Reactivity:Human, Mouse

Clonality:Monoclonal

Clone ID:8E3A7

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MSH6

Immunogen:Purified recombinant fragment of human MSH6 (AA: 217-395) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):50kDa

UniProt accession:Q13509

Synonyms:CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4, beta-4

GeneID:10381