Mouse Secretin receptor,SCTR ELISA KIT

SKU: E1142Mo

Size:96 Tests-1 Kit

Background:Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:20927047, PubMed:24273196, PubMed:30449620). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (PubMed:30449620). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (PubMed:30449620). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (PubMed:30449620). Also able to stimulate lipolysis in white adipocytes (PubMed:24273196). Also plays an important role in cellular osmoregulation by regulating renal water reabsorption (PubMed:17283064). Also plays a role in the central nervous system: required for synaptic plasticity (PubMed:17008357). {ECO:0000250|UniProtKB:P11384, ECO:0000269|PubMed:17008357, ECO:0000269|PubMed:17283064, ECO:0000269|PubMed:20927047, ECO:0000269|PubMed:24273196, ECO:0000269|PubMed:30449620}.

Research_area:

Applications:ELISA

Target_protein:Sctr

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.05ng/mL

Detection range:0.1-6.4ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:secretin receptor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q5FWI2

MASS(Da):50932

GeneID:319229

Synonyms:Sctr

Gene names:Sctr

Standard solution:12.8ng/mL