Mouse Proinsulin, PI ELISA Kit

SKU: E0390Mo

Size:96 Tests-1 Kit

Background:Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28073925, PubMed:8496151, PubMed:28541286, PubMed:28453791, PubMed:20026663, PubMed:23041626, PubMed:27789271, PubMed:12524533). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286, PubMed:27789271). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (PubMed:12524533). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:8496151). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:23041626, PubMed:20026663). Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity.

Research_area:Signal Transduction; Cancer; Immunology

Applications:ELISA

Target_protein:PI

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.56ng/L

Detection range:1-400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Proinsulin

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P28798

MASS(Da):63,458

GeneID:14824

Synonyms:Acrogranin;epit;Epithelin/granulin precursor;Glycoprotein 88;Glycoprotein of 88 Kda;GP88;Granulin-1;Granulin-2;Granulin-3;Granulin-4;Granulin-5;Granulin-6;Granulin-7];Paragranulin;PC cell-derived growth factor;PCDGF;PEPI;Pgrn;PI;pr;Proepithelin;Progranulin;

Gene names:Grn

Standard solution:480ng/L