Mouse Peroxisome Proliferator-activated Receptor Gamma Coactivator 1 Alpha, PGC1A ELISA Kit

SKU: E1487Mo

Size:96 Tests-1 Kit

Background:Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. Isoform 4 specifically activates the expression of IGF1 and suppresses myostatin expression in skeletal muscle leading to muscle fiber hypertrophy.

Research_area:Metabolism

Applications:ELISA

Target_protein:PPARGC1A

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:7.33ng/L

Detection range:15-3000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 Alpha

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O70343

MASS(Da):90,588

GeneID:19017

Synonyms:Peroxisome proliferator-activated receptor gamma coactivator 1-alpha;PGC-1-alpha;PPAR-gamma coactivator 1-alpha;PPARGC 1A;PPARGC1A;PPARGC-1-alpha

Gene names:PPARGC1A

Standard solution:3200ng/L