Mouse Leukocyte Elastase Inhibitor A,Serpinb1a ELISA KIT

SKU: E0757Mo

Size:96 Tests-1 Kit

Background:Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:17664292, PubMed:21683252, PubMed:21248149, PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection (PubMed:17664292). These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of granzyme H (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). In addition, promotes the proliferation of beta-cells when secreted (PubMed:26701651). {ECO:0000269|PubMed:12189154, ECO:0000269|PubMed:17664292, ECO:0000269|PubMed:21248149, ECO:0000269|PubMed:21683252, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}.

Research_area:

Applications:ELISA

Target_protein:Serpinb1a

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Leukocyte Elastase Inhibitor A

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9D154

MASS(Da):42575

GeneID:66222

Synonyms:Serpinb1a Serpinb1

Gene names:Serpinb1a

Standard solution:24ng/ml