Mouse Kremen protein 1,KREMEN1 ELISA KIT

SKU: E1214Mo

Size:96 Tests-1 Kit

Background:Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540). {ECO:0000250|UniProtKB:Q90Y90, ECO:0000269|PubMed:12050670, ECO:0000269|PubMed:18505822, ECO:0000269|PubMed:26206087, ECO:0000269|PubMed:27550540}.

Research_area:

Applications:ELISA

Target_protein:Kremen1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:49.95pg/ml

Detection range:100-6400pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Kremen protein 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99N43

MASS(Da):51673

GeneID:84035

Synonyms:Kremen1 Kremen

Gene names:Kremen1

Standard solution:12800pg/ml