Mouse Intelectin-1, ITLN1/OMENTIN ELISA Kit

SKU: E0145Mo

Size:96 Tests-1 Kit

Background:Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery (PubMed: 1006$458.00|$300.003). Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin-coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors (PubMed: 16914641). Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2 (By similarity). Promotes ubiquitination and subsequent degradation of EGFR, and thereby contributes to the down-regulation of EGFR-dependent signaling pathways (PubMed: 16914641). In chromaffin cells, required for normal exocytosis of catecholamines (PubMed: 18676989). Required for rapid replenishment of release-ready synaptic vesicles at presynaptic active zones (PubMed: 23633571). Inhibits ARHGAP31 activity toward RAC1 (By similarity). [Isoform 1]: Plays a role in synaptic vesicle endocytosis in brain neurons.

Research_area:Others

Applications:ELISA

Target_protein:ITSN1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.57ng/mL

Detection range:1-380ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Intelectin-1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z0R4

MASS(Da):194,297

GeneID:16443

Synonyms:EH and SH3 domains protein 1;Intersectin-1;ITSN 1;ITSN1

Gene names:ITSN1

Standard solution:400ng/mL