Mouse IL-12(p40) ELISA Kit PicoKine®

SKU: EK0932

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: IL12B

Specificity: Natural and recombinant mouse IL-12(p40)

Background: Interleukin-12 (IL12, formerly NKSF, for natural killer cell stimulatory factor, or CLMF, for cytotoxic lymphocyte maturation factor) is a novel cytokine cloned from B-cell lines. IL-12 is a heterodimeric molecule composed of p35 and p40 subunits.1 The larger 40-kDa subunit (p40) is a member of the cytokine receptor family, and the smaller 35-kDa subunit (p35) is related to IL6 and GCSF.2 Both IL-12 p40 (-/-) and p35 (-/-) mice fail to produce IL-12 p70 heterodimer.3 Interleukin (IL)-12 has been cloned on the basis of its ability to activate natural killer (NK) cells and promote the development of cytolytic T cells. With further understanding of its activities, IL-12 has emerged as an important cytokine, affecting both immune and hematologic functions. It has been shown to be necessary for the T cell independent induction of interferon (IFN)-gamma, critical for the initial suppression of bacterial and parasitic infection; for the development of a Th1 response, critical for effective host defense against intracellular pathogens; and for the activation of differentiated T lymphocytes of both CD4+ and CD8+ phenotype.

Immunogen: Expression system for standard: NS0; Immunogen sequence: M23-S335

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Uniprot ID: P43432

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 16160

Protein Name: Interleukin-12 subunit beta

Gene Full Name: interleukin 12b

Synonyms: CLMF; CLMF p40; CLMF2; IL 12 subunit p40; IL 12B; IL12B; IL-12B; Interleukin 12 subunit beta; NKSF; NKSF2