Mouse Frizzled-8,FZD8 ELISA KIT

SKU: E1006Mo

Size:96 Tests-1 Kit

Background:Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000250, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:10395542, ECO:0000269|PubMed:15454084, ECO:0000269|PubMed:16543246}.

Research_area:

Applications:ELISA

Target_protein:Fzd8

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:10.09pg/ml

Detection range:18.75-1200pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Frizzled-8

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q61091

MASS(Da):73045

GeneID:14370

Synonyms:Fzd8

Gene names:Fzd8

Standard solution:2400pg/ml