Mouse Filamin-A, FLNA ELISA Kit

SKU: E2077Mo

Size:96 Tests-1 Kit

Background:Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs (PubMed: 17172441). Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (PubMed: 20713593). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed: 25358863).

Research_area:Others

Applications:ELISA

Target_protein:FLNA

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.54ng/L

Detection range:1-400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Filamin-A

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8BTM8

MASS(Da):281,222

GeneID:192176

Synonyms:ABP-280;Actin-binding protein 280;Alpha-filamin;Endothelial actin-binding protein;Filamin-1;Filamin-A;FLNA;FLN-A;Non-muscle filamin;

Gene names:FLNA

Standard solution:480ng/L