Mouse Endostatin PicoKine® Quick ELISA Kit

SKU: FEK1376

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Col18a1

Specificity: Natural and recombinant mouse Col18a1

Background: Endostatin is a naturally-occurring 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. And It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Using a genomic clone as a probe for fluorescence in situ hybridization, Endostatin was mapped the COL18A1 gene to 21q22.3. By immunoprecipitation analysis using membrane fractions of human mammary epithelial cells, It showed that endostatin specifically bound to cell surface nucleolin with high affinity. Blockage of nucleolin with neutralizing antibody or knockdown of nucleolin by RNA interference countered the antiendothelial activity of endostatin and abrogated its antiangiogenic and antitumor activity in vivo.

Immunogen: Expression system for standard: NS0; Immunogen sequence: H1591-K1774

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Reference:

Uniprot ID: P39061

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 12822

Protein Name: Collagen alpha-1

Gene Full Name: collagen, type XVIII, alpha 1

Synonyms: COL18A1; Collagen alpha 1(XVIII) chain; collagen; type XVIII; alpha 1; Endostatin; KNO; KNO1