Mouse Complement Factor H, CFH ELISA Kit

SKU: E0592Mo

Size:96 Tests-1 Kit

Background:Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors. For example, interacts with CR3/ITGAM receptor and thereby mediates the adhesion of human neutrophils to different pathogens. In turn, these pathogens are phagocytosed and destroyed.

Research_area:Immunology

Applications:ELISA

Target_protein:CFH

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.76ng/mL

Detection range:20-4500ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Complement Factor H

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P06909

MASS(Da):139,138

GeneID:12628

Synonyms:CFH;Complement factor H;Protein beta-1-H

Gene names:CFH

Standard solution:4800ng/mL