Mouse Collagen alpha-1(XVIII) chain,COL18A1 ELISA KIT

SKU: E1248Mo

Size:96 Tests-1 Kit

Background:Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. {ECO:0000250|UniProtKB:P39060}.; [Non-collagenous domain 1]: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling. {ECO:0000250|UniProtKB:P39060}.; [Endostatin]: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (PubMed:9008168). Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2 (PubMed:12029087). Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:11158588). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (By similarity). {ECO:0000250|UniProtKB:P39060, ECO:0000269|PubMed:11158588, ECO:0000269|PubMed:9008168}.

Research_area:

Applications:ELISA

Target_protein:Col18a1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.023ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Collagen alpha-1,18 chain

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P39061

MASS(Da):182172

GeneID:12822

Synonyms:Col18a1

Gene names:Col18a1

Standard solution:24ng/ml