Mouse Cd81 Antigen, CD81 ELISA Kit

SKU: E1921Mo

Size:96 Tests-1 Kit

Background:Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells (PubMed:23499492). Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells (By similarity). Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response (PubMed:11046035). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. In myoblasts, associates with another tetraspanin CD9 in complex with PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Positively regulates sperm-egg fusion and may be involved in the acrosome reaction (PubMed:16380109, PubMed:17290409). Regulates protein trafficking in intracellular compartments. In T cells, associates with dNTPase SAMHD1 and defines its subcellular location, enabling its degradation by the proteasome and thereby controlling intracellular dNTP levels (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991). (Microbial infection) Specifically required for Plasmodium yoelii infectivity of hepatocytes, controlling sporozoite entry in hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms.

Research_area:Immunology; Microbiology

Applications:ELISA

Target_protein:CD81

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.85ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:CD81 antigen

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P35762

MASS(Da):25,815

GeneID:12520

Synonyms:26 kDa cell surface protein TAPA-1;CD antigen CD81;CD81;CD81 antigen;Ta;Tap;Tapa1;Tapa-1;Target of the antiproliferative antibody 1;Tsp;Tspan28

Gene names:Cd81

Standard solution:6400ng/L