Mouse Beta-catenin,CTNNB1 ELISA KIT

SKU: E0198Mo

Size:96 Tests-1 Kit

Background:Key downstream component of the canonical Wnt signaling pathway (PubMed:15132997). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (PubMed:16325582, PubMed:18093941). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (PubMed:21325504). Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (PubMed:15132997). {ECO:0000250|UniProtKB:P35222, ECO:0000269|PubMed:15132997, ECO:0000269|PubMed:16325582, ECO:0000269|PubMed:18093941, ECO:0000269|PubMed:21325504}.

Research_area:

Applications:ELISA

Target_protein:Ctnnb1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.052ng/ml

Detection range:0.1-30ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:β-catenin

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q02248

MASS(Da):85471

GeneID:12387

Synonyms:Ctnnb1 Catnb

Gene names:Ctnnb1

Standard solution:32ng/ml