Mouse Bcl2;adenovirus E1B 19 kDa protein-interacting protein 3,BNIP3 ELISA KIT

SKU: E1064Mo

Size:96 Tests-1 Kit

Background:Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity). {ECO:0000250}.

Research_area:

Applications:ELISA

Target_protein:Bnip3

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:46.9pg/ml

Detection range:100-6400pg/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Bcl2;Adenovirus E1B 19kDa Interacting Protein 3

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O55003

MASS(Da):20978

GeneID:12176

Synonyms:Bnip3 Nip3

Gene names:Bnip3

Standard solution:12800pg/ml