Mouse Autophagy related protein 5,ATG5 ELISA KIT

SKU: E2639Mo

Size:96 Tests-1 Kit

Background:Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:17190837, ECO:0000269|PubMed:17912025, ECO:0000269|PubMed:18188005, ECO:0000269|PubMed:19844159, ECO:0000269|PubMed:20171125, ECO:0000269|PubMed:24089205, ECO:0000269|PubMed:24089209}.; May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD (By similarity). {ECO:0000250|UniProtKB:Q9H1Y0}.; (Microbial infection) May act as a proviral factor. In association with ATG12, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. {ECO:0000269|PubMed:17709747}.

Research_area:

Applications:ELISA

Target_protein:Atg5

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:3.03ng/L

Detection range:5-1800ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Autophagy related protein 5

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99J83

MASS(Da):32402

GeneID:11793

Synonyms:Atg5 Apg5l

Gene names:Atg5

Standard solution:1920ng/L