MIA3 Antibody, HRP conjugated - Cat. #: CSB-PA711448LB01HU

SKU: CSB-PA711448LB01HU

Size :50ug

Clone Number:

Aliases:ARNT antibody; C219 reactive peptide antibody; C219-reactive peptide antibody; D320 antibody; Melanoma inhibitory activity family; member 3 antibody; Melanoma inhibitory activity protein 3 antibody; Mia3 antibody; MIA3_HUMAN antibody; RP11-378J18.4 antibody; TANGO antibody; Transport and Golgi organization protein 1 antibody; UNQ6077 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q5JRA6

Immunogen:Recombinant Human Transport and Golgi organization protein 1 homolog protein (1447-1626AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum (PubMed:27138255, PubMed:19269366). Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of CTAGE5 and PREB/SEC12 to ERES (PubMed:28442536).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MIA3

Research Areas:Signal transduction