MeCP2 rabbit pAb

SKU: ES20671

Size: 100μL

Source:Rabbit

Applications:WB

Reactivity:Human

Dilution:WB: 1:2000

Immunogen:Synthetic Peptide of MeCP2 AA range: 313-363

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:

Observed_band(KD):53kD

Human_gene_id:4204

Human_swiss_prot_no:P51608

Subcellular_location:Nucleus . Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. .

Other_name:Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Background:DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor