MDC1 Polyclonal Antibody

SKU: E-AB-12802

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: MDC1

Target Synonym: Homologue to Drosophila photoreceptor protein calphotin;MDC 1;Mdc1;MDC1;Mediation of DNA damage checkpoint 1;Mediator of DNA damage checkpoint 1;Mediator of DNA damage checkpoint protein 1;NFBD 1;NFBD1;Nuclear factor with BRCT domains 1;Nuclear Factor with BRCT Domains Protein 1

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q14676

Accession:

Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Concentration: 1.2 mg/mL

Immunogen: Synthetic peptide of human MDC1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:100-1:300

Calculated MW:

ObservedMW: