MDC1 antibody , Cat. # FNab05072

SKU: FNab05072

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

Immunogen:mediator of DNA damage checkpoint 1

Synonyms:KIAA0170, NFBD1

Observed MW:270 kDa

Uniprot ID:Q14676

Reactivity:Human

Tested Application:ELISA, IHC, WB

Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:100 - 1:200

Gene ID:9656

Research Area:Epigenetics, Metabolism