MAPK9 Monoclonal Antibody

SKU: BT-MCA3175

Size:100μL

Background:The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Research_area:Signal Transduction

Target_protein:MAPK9

applications:WB, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:2F6H11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MAPK9

Immunogen:Purified recombinant fragment of human MAPK9 (AA: 227-382) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):48.1kDa

UniProt accession:P45984

Synonyms:JNK2, SAPK, p54a, JNK2A, JNK2B, PRKM9, JNK-55, SAPK1a, JNK2BETA, p54aSAPK, JNK2ALPHA

GeneID:5601