MAFB Antibody - Cat. #: CSB-PA897570LA01HU

SKU: CSB-PA897570LA01HU

Size :50ug

Clone Number:

Aliases:Kreisler antibody; Kreisler (mouse) maf related leucine zipper homolog antibody; Kreisler maf related leucine zipper homolog antibody; KRML antibody; MAF bZIP transcription factor B antibody; Maf-B antibody; Mafb antibody; MAFB/Kreisler basic region/leucine zipper transcription factor antibody; MAFB_HUMAN antibody; MGC43127 antibody; Segmentation protein KR antibody; Transcription factor MafB antibody; V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y5Q3

Immunogen:Recombinant Human Transcription factor MafB protein (168-323AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MAFB

Research Areas:Epigenetics and Nuclear Signaling