LOXL2 Antibody - Cat. #: CSB-PA897283LA01HU

SKU: CSB-PA897283LA01HU

Size :50ug

Clone Number:

Aliases:LOR 2 antibody; LOR2 antibody; LOX L2 antibody; LOXL 2 antibody; LOXL2 antibody; LOXL2_HUMAN antibody; Lysyl oxidase homolog 2 antibody; Lysyl oxidase like 2 antibody; Lysyl oxidase like protein 2 antibody; Lysyl oxidase related 2 antibody; Lysyl oxidase related protein 2 antibody; Lysyl oxidase related protein WS9 14 antibody; Lysyl oxidase-like protein 2 antibody; Lysyl oxidase-related protein 2 antibody; Lysyl oxidase-related protein WS9-14 antibody; WS9 14 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9Y4K0

Immunogen:Recombinant Human Lysyl oxidase homolog 2 protein (27-121AA)

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background:Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated \\\'Lys-4\\\' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LOXL2

Research Areas:Cancer; Signal transduction