liver Arginase antibody , Cat. # FNab04801

SKU: FNab04801

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:4A0

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Arginase-1(Liver arginase) belongs to the arginase family. ARG1 is a novel immunohistochemical?marker?of hepatocellular differentiation in fine needle aspiration cytology and a marker?of hepatocytes and hepatocellular neoplasms. ARG1 is closely associated with alternative macrophage activation(PMID:12098359) and ARG1 has been shown to protectmotor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins(PMID: 20071539).It can exsit as a homotrimer(PMID:16141327) and it has 3 isoforms produced by alternative splicing.Defects in ARG1 are the cause of argininemia(ARGIN). Deletion or TNF-mediated restriction of ARG1 unleashes the production of NO by NOS2, which is critical for pathogen control.(PMID:27117406).

Immunogen:arginase, liver

Synonyms:ARG1, Arginase 1, liver Arginase, Liver type arginase

Observed MW:35 kDa

Uniprot ID:P05089

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, WB, IHC

Recommended dilution:WB: 1:1000-1:8000; IHC: 1:200-1:1000

Gene ID:383

Research Area:Signal Transduction, Metabolism