LIG4 Antibody - Cat. #: CSB-PA869550

SKU: CSB-PA869550

Size :100ul

Clone Number:

Aliases:DNA ligase IV ATP dependent antibody; DNA joinase antibody; DNA ligase 4 antibody; DNA ligase IV antibody; DNA repair enzyme antibody; DNLI4_HUMAN antibody; LIG 4 antibody; LIG4 antibody; LIG4S antibody; Ligase IV antibody; Ligase IV DNA ATP dependent antibody; Polydeoxyribonucleotide synthase [ATP] 4 antibody; Polydeoxyribonucleotide synthase 4 antibody; Polydeoxyribonucleotide synthase antibody; Polynucleotide ligase antibody; Sealase antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P49917

Immunogen:Synthesized peptide derived from internal of Human DNL4.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Wei Y.-F., Mol. Cell. Biol. 15:3206-3216(1995).
Dunham A., Nature 428:522-528(2004).
Robins P., J. Biol. Chem. 271:24257-24261(1996).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LIG4

Research Areas:Epigenetics and Nuclear Signaling