LDLR Monoclonal Antibody

SKU: BT-MCA4751

Size:100μL

Background:The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

Research_area:Cancer, Cardiovascular, Metabolism, Signal transduction

Target_protein:LDLR

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:7H5B11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:LDLR

Immunogen:Purified recombinant fragment of human LDLR (AA: 22-150) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):95.4kDa

UniProt accession:P01130

Synonyms:FH, FHC, LDLCQ2

GeneID:3949