LCN2 Monoclonal Antibody - Cat. #: CSB-MA068341A0m

SKU: CSB-MA068341A0m

Size :50ug

Clone Number:3B1C10

Aliases:NGAL,25 kDa alpha-2-microglobulin-related subunit of MMP-9,Lipocalin-2

Product Type:Monoclonal Antibody

Immunogen Species:Human

UniProt ID:P80188

Immunogen:Recombinant Human Neutrophil gelatinase-associated lipocalin protein

Raised in:Mouse

Species Reactivity:Human,Mouse

Tested Applications:ELISA,WB;Recommended dilution:WB:1:500-1:5000

Background:Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Clonality:Monoclonal

Isotype:IgG2b

Purification Method:>95%,Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LCN2

Research Areas:Cancer?Cardiovascular;Immunology?Metabolism;Signal transduction