LAT (Ab-255) Antibody - Cat. #: CSB-PA153832

SKU: CSB-PA153832

Size :100ul

Clone Number:

Aliases:36 kDa phospho tyrosine adapter protein antibody; 36 kDa phospho-tyrosine adapter protein antibody; 36 kDa phospho-tyrosine adaptor protein antibody; LAT 1 antibody; lat antibody; LAT_HUMAN antibody; LAT1 antibody; Linker for activation of T cells antibody; Linker for activation of T cells family member 1 antibody; linker for activation of T cells; transmembrane adaptor antibody; Linker for activation of T-cells family member 1 antibody; p36 38 antibody; p36-38 antibody; pp36 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43561

Immunogen:Synthesized non-phosphopeptide derived from Human LAT around the phosphorylation site of tyrosine 255.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

Zhang W., Cell 92:83-92(1998).
Martin J., Nature 432:988-994(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LAT

Research Areas:Immunology;Signal transduction