KMT2A Monoclonal Antibody

SKU: BT-MCA2037

Size:100μL

Background:This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

Research_area:Others

Target_protein:KMT2A

applications:

Reactivity:Human

Clonality:Monoclonal

Clone ID:4A5A12

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:KMT2A

Immunogen:Purified recombinant fragment of human KMT2A (AA: 801-956) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):431.7kDa

UniProt accession:Q03164

Synonyms:HRX, MLL, MLL1, TRX1, ALL-1, CXXC7, HTRX1, MLL1A, WDSTS

GeneID:4297