KIT Monoclonal Antibody

SKU: BT-MCA2497

Size:100μL

Background:The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.

Research_area:Immunology

Target_protein:KIT

applications:WB, IHC

Reactivity:Human

Clonality:Monoclonal

Clone ID:1C5

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:KIT

Immunogen:Purified recombinant fragment of human KIT expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):145kDa

UniProt accession:P10721

Synonyms:PBT, SCFR, C-Kit, CD117

GeneID:3815