KDR Monoclonal Antibody

SKU: BT-MCA2943

Size:100μL

Background:KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Research_area:Cardiovascular

Target_protein:KDR

applications:ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4B4

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:KDR

Immunogen:Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Ascitic fluid containing 0.03% sodium azide.

Concentration:

Molecular weight(Da):152kDa

UniProt accession:P35968

Synonyms:FLK1, CD309, VEGFR, VEGFR2

GeneID:3791